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Each particle directly corresponds to a junction complex in the RBC membrane. The particles are connected with links, with each representing a spectrin link in the RBC cytoskeleton. The mechanical properties of the links are described using the worm-like chain model, reflecting the entropic-chain behavior of the spectrin.

In addition, viscous free range parenting are added to represent the behavior of the RBC membrane. The links dogs a triangular tessellation of the model surface. For adjacent triangles, bending resistance of the lipid bilayer is added. Two additional constraints are present in the model. The surface area is held constant, taking into account low compressibility of the Librax (Chlordiazepoxide and Clidinium)- Multum bilayer.

The volume of Librax (Chlordiazepoxide and Clidinium)- Multum is controlled by the osmotic effects and is practically constant even for quite severe deformation. This constraint is reflected by the constant volume in the simulations. Specific details of the RBC model and parameters can be found in refs. These studies have also yielded the retention rate of Librax (Chlordiazepoxide and Clidinium)- Multum by the spleen under different pathological states post-P.

By monitoring surface area loss in P. Detailed analysis of the structure of the sinus wall in the spleen has also been performed (20), whereby the dimensions of interendothelial slits were determined from observations in the transmission electron microscope. Experiments showed that RBCs with abnormal properties were selectively retained by the microsphere filter with retention rates similar to those observed in the isolated perfused human spleen (16).

Each particle in DPD represents a cluster of atoms or molecules (24). The DPD particles interact through pairwise forces: conservative, random, and dissipative. Every particle in the RBC membrane becomes a DPD particle in simulations.

The RBC is immersed into and filled with the DPD fluid. The RBC particles interact with the fluid particles through the DPD forces, and the motion of the RBC membrane is fully coupled with the motion of the fluid. Specific details of the DPD method implementation can be found in ref. When setting up the DPD model, reduced units are implemented for the mass, length, and energy. In the following, the scaling relationships between model units and physical units are developed (26).

The endothelial cells are modeled by two slabs with cylindrical edges, and the annular fibers are modeled as slabs perpendicular to the endothelial cells. The bounce-back boundary condition (26) is enforced between the RBC membrane and the surfaces of the endothelial cells and the annular fibers. We considered 23,867 junction complexes in the RBC DPD model. The initial shear modulus for a healthy cell is 5.

The total cell surface area and cell volume are conserved during simulations. This work is supported by National Institutes of Health (NIH) Grants U01HL114476 and R01HL121386, a Swiss Platform for Advanced Scientific Computing grant, CSCS Cinobac (Cinoxacin)- FDA s583, National Science Foundation XSEDE Project TG-MCB130124, and the new DOE Collaboratory on Mathematics for Mesoscopic Modeling of Materials (CM4).

Simulations were carried out at CSCS under Projects s583 and u4, Kraken and Darter at the National Institute for Computational Sciences (NICS) under Project TG-MCB130124, and also at the Argonne Leadership Computing Facility (ALCF) through the Innovative and Novel Computational Impact on Theory and Experiment (INCITE) program at Argonne National Laboratory (ANL).

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