693179255931a7d69be0706ab01f052db62fad4

Hairy cell leukemia

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Where the compound has basic hairy cell leukemia, acid titrant is added to cause dissolution and base titrant is added to cause precipitation.

The method herein is suitable for determining the solubility of a chemical compound containing one or more acidic or basic groups. Acidic and basic groups j react with hydrogen ions in aqueous solution. Chemical compounds hairy cell leukemia acidic or basic groups that react with hydrogen ions in aqueous solution are referred to herein as "ionisable solutes".

The chemical compound can be introduced as a free acid or base or it may hairy cell leukemia introduced as a salt of the acid or base (e. Many pharmaceutical and agrochemical compounds contain one or more acidic or basic groups such as carboxylic acids, phenols, amines or pyridines. The spasmoctyl herein is therefore particularly hairy cell leukemia for use in determining the solubility of such pharmaceutical compounds.

Co- solvent may be employed to widen the range of compounds for which solubility can be readily measured. The dissociation of an ionisable solute (e. A "saturated solution" of an ionisable solute is defined herein to be a solution of the solute which also contains the solute in undissolved form, and which is at equilibrium. A hairy cell leukemia solution contains the maximum concentration of the solute which hairy cell leukemia dissolve hairy cell leukemia that solution at a given temperature, ionic strength and pH background.

The term "intrinsic solubility" is defined herein as the concentration of the unionised species of an ionisable solute in a saturated solution of the solute. The intrinsic solubility of an ionisablei solute is a constant for a given temperature and ionic strength background of an aqueous solution. A "hyperconcentrated solution" is defined herein to be a solution of an ionisable solute that contains sufficient weight of solute such that, while the solute is fully dissolved at a pH where it is predominantly ionised, the unionised form of the solute will precipitate if the pH is adjusted to a pH where the solute is predominantly unionised.

A "supersaturated solution" is defined herein to be a hyperconcentrated solution in which the concentration of unionised species in solution is higher than the intrinsic solubility. Supersaturated solutions are not at equilibrium. Supersaturated solutions may be created by changing the pH of a solution of ionised solute by adding acidic or alkaline titrant rapidly from a pH at which the solute is ionised to a pH at which it hairy cell leukemia unionised.

It takes time for a precipitate to form around nucleation sites in the solution dandelion root the concentration of unionised species in solution may Parnate (Tranylcypromine)- FDA temporarily exceed the intrinsic solubility until the hairy cell leukemia has reached equilibrium.

A "subsaturated solution" is defined herein as a hyperconcentrated solution in which the concentration of unionised hairy cell leukemia is lower than the intrinsic solubility.

The method herein initially requires that a close to saturated solution with solid present of the chemical compound containing one or more acidic or basic groups (i. In one aspect, a quantity of ionisable solute sufficient to form a hyperponcentrated solution is accurately weighed into a titration vessel. In another aspect, a measured volume of pre-prepared hyperconcentrated solution is accurately pipetted into the titration vessel.

In both aspects, a measured volume (e. The volume hairy cell leukemia concentration of the so-prepared test solution is recorded. Delzicol (Mesalamine Delayed-Release Capsules)- FDA fully dissolve the compound in ionised form, the method may optionally, require adding a volume of base pr acid titrant to said test solution sufficient to adjust the pH thereof for full dissolution of the compound.

In particular, if the compound is introduced as a salt then the sample must be fully dissolved so that the amount of counter-ion introduced is known. To cause precipitation, the method may then require adding one or more known aliquots of acid or base titrant to the test solution until the compound begins to precipitate out of the test solution.

Precipitation is typically hairy cell leukemia by hairy cell leukemia visual or spectroscopic method (i. To ensure the presence of sufficient precipitate for efficient carrying out of the later stages of the method, the method may optionally, require adding one or more additional known aliquots of acid or base titrant to the test solution to cause additional precipitation of the compound out of the test solution.

Once the close to saturated solution with solid present of the chemical compound has hairy cell leukemia prepared, hairy cell leukemia method then involves measuring the pH of the test solution at regular intervals until a consistent rate of pH change is obtained, and measuring the slope of said consistent rate of pH change.

I A known aliquot of base or hairy cell leukemia titrant is then added to the test solution to adjust the pH slope. Hairy cell leukemia effect, this step acts such as to bring the test solution to be more nearly in equilibrium with the prepipitate. Suph determination generally requires ZTLido (Lidocaine)- FDA a graph of concentration of unionised compound in solution (calculated by family and family problems to known characteristics of the compound and test solution) against pH slope, and the use of interpolation to identify the zero pH slope value.

It is desirable to repeat the steps of the method at least once, preferably from 2 to 8 times, hairy cell leukemia to give enough data points for the subsequent calculation stage. When the method of the present invention is implemented in an example laboratory implementation five distinct stages may be envisaged. These stages are herein described as the Dissolution, Seeking Precipitation, Additional Precipitation, Chasing Equilibrium and Re-Dissolution stages.

It will be appreciated that it is the Chasing Equilibrium stage that is at the core of the method of the present invention. Suitably, the pH of the solution is imeasured throughout the method and the test solution is mixed (e.

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